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KMID : 0604520200460040391
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Journal of the Society of Cosmetic Scientists of Korea
2020 Volume.46 No. 4 p.391 ~ p.401
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Roles of Fisetin on Skin Barrier Function and Anti-aging in Epidermal Keratinocyte
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Lee Kyung-Ha
Kim Wan-Il
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Abstract
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Flavonoids are polyphenolic compounds derived from plants metabolites and are known to be capable of controlling various human physiological functions. Among them, fisetin (3,3’, 3’, 7-tetrahydroxyflavone) is found in various fruits and vegetables, and it has been recently known to restore the function of certain tissues through senolytic activity. In this study, targeting human epidermal keratinocytes, control of skin barrier genes and antioxidant efficacy of fisetin were analyzed. Fisetin increased the activity of telomerase and decreased the expression of CDKN1B. In addition, it increased the expression of KRT1, FLG, IVL, and DSP, which are main genes that make up the skin barrier. The fisetin also increased the expression of CerS3 and CerS4 genes, which are forms of ceramide synthases. These results show that the efficacy of fisetin is not limited as senolytics but is also involved in various physiological regulation of human keratinocytes. Therefore, we consider that fisetin could be used as an active ingredient in cosmetics and pharmaceuticals.
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KEYWORD
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fisetin, senolytics, keratinocyte, skin barrier, anti-aging
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